High throughput single cell long-read sequencing analyses of same-cell genotypes and phenotypes in human tumors

High throughput single cell long-read sequencing analyses of same-cell genotypes and phenotypes in human tumors

Abstract Single-cell nanopore sequencing of full-length mRNAs transforms single-cell multi-omics studies. However, challenges include high sequencing errors and dependence on short-reads and/or barcode whitelists. To address these, we develop scNanoGPS to calculate same-cell genotypes (mutations) an...

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Bibliographic Details
Main Authors: Cheng-Kai Shiau, Lina Lu, Rachel Kieser, Kazutaka Fukumura, Timothy Pan, Hsiao-Yun Lin, Jie Yang, Eric L. Tong, GaHyun Lee, Yuanqing Yan, Jason T. Huse, Ruli Gao
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-39813-7

Internet

https://doi.org/10.1038/s41467-023-39813-7

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