Investigation of inner ear drug delivery with a cochlear catheter in piglets as a representative model for human cochlear pharmacokinetics

Investigation of inner ear drug delivery with a cochlear catheter in piglets as a representative model for human cochlear pharmacokinetics

Hearing impairment is the most common sensory disorder in humans, and yet hardly any medications are licensed for the treatment of inner ear pathologies. Intricate pharmacokinetic examinations to better understand drug distribution within this complex organ could facilitate the development of novel...

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Bibliographic Details
Main Authors: Erdem Yildiz, Anselm J. Gadenstaetter, Matthias Gerlitz, Lukas D. Landegger, Rudolfs Liepins, Michael Nieratschker, Rudolf Glueckert, Hinrich Staecker, Clemens Honeder, Christoph Arnoldner
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
drug delivery
large animal model
pharmacokinetics
SNHL = sensorineural hearing loss
inner ear catheter
pig
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1062379/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1062379/full

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