Oxostephanine, Thalmiculine, and Thaliphyline—Three Isoquinoleine Alkaloids That Inhibit L-Type Voltage-Gated Ca<sup>2+</sup> Channels

Oxostephanine, Thalmiculine, and Thaliphyline—Three Isoquinoleine Alkaloids That Inhibit L-Type Voltage-Gated Ca<sup>2+</sup> Channels

The isoquinoline alkaloids (IAs) represent a large and diverse subfamily of phytochemicals in terms of structures and pharmacological activities, including ion channel inhibition. Several IAs, such as liriodenine (an oxoaporphine) and curine (a bisbenzylisoquinoline (BBIQ), inhibit the L-type voltag...

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Bibliographic Details
Main Authors: Jacinthe Frangieh, Claire Legendre, Dimitri Bréard, Pascal Richomme, Daniel Henrion, Ziad Fajloun, César Mattei, Anne-Marie Le Ray, Christian Legros
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Future Pharmacology
Subjects:
isoquinoline alkaloids
L-type voltage-gated Ca<sup>2+</sup> channels
intracellular Ca<sup>2+</sup> measurement
Fura-2 fluorescent probe
GH3b6 cells
Online Access:https://www.mdpi.com/2673-9879/2/3/16

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https://www.mdpi.com/2673-9879/2/3/16

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