Therapeutic effects of adipose-derived mesenchymal stem/stromal cells with enhanced migration ability and hepatocyte growth factor secretion by low-molecular-weight heparin treatment in bleomycin-induced mouse models of systemic sclerosis

Therapeutic effects of adipose-derived mesenchymal stem/stromal cells with enhanced migration ability and hepatocyte growth factor secretion by low-molecular-weight heparin treatment in bleomycin-induced mouse models of systemic sclerosis

Abstract Background Adipose-derived mesenchymal stem cells (ASCs) have gained attention as a new treatment for systemic sclerosis (SSc). Low-molecular-weight heparin (LMWH) enhances cell function and stimulates the production of hepatocyte growth factor (HGF) in a variety of cells. This study invest...

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Bibliographic Details
Main Authors: Takayasu Suzuka, Takuya Kotani, Takashi Saito, Shogo Matsuda, Takako Sato, Tohru Takeuchi
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Arthritis Research & Therapy
Subjects:
Adipose-derived mesenchymal stem/stromal cells
Low-molecular-weight heparin
Hepatocyte growth factor
Systemic sclerosis
Online Access:https://doi.org/10.1186/s13075-022-02915-6

Internet

https://doi.org/10.1186/s13075-022-02915-6

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