Effect of Different Direct Compaction Grades of Mannitol on the Storage Stability of Tablet Properties Investigated Using a Kohonen Self-Organizing Map and Elastic Net Regression Model

Effect of Different Direct Compaction Grades of Mannitol on the Storage Stability of Tablet Properties Investigated Using a Kohonen Self-Organizing Map and Elastic Net Regression Model

This study tested 15 direct compaction grades to identify the contribution of different grades of mannitol to the storage stability of the resulting tablets. After preparing the model tablets with different values of hardness, they were stored at 25 °C, 75% relative humidity for 1 week. Then, measur...

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Bibliographic Details
Main Authors: Atsushi Kosugi, Kok Hoong Leong, Eri Urata, Yoshihiro Hayashi, Shungo Kumada, Kotaro Okada, Yoshinori Onuki
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Pharmaceutics
Subjects:
excipient
storage stability
tablet
mannitol
Kohonen self-organizing map
Elastic net regression
Online Access:https://www.mdpi.com/1999-4923/12/9/886

Internet

https://www.mdpi.com/1999-4923/12/9/886

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