pncA Gene Mutations Associated with Pyrazinamide Resistance in Drug-Resistant Tuberculosis, South Africa and Georgia

pncA Gene Mutations Associated with Pyrazinamide Resistance in Drug-Resistant Tuberculosis, South Africa and Georgia

Although pyrazinamide is commonly used for tuberculosis treatment, drug-susceptibility testing is not routinely available. We found polymorphisms in the pncA gene for 70% of multidrug-resistant and 96% of extensively drug-resistant Mycobacterium tuberculosis isolates from South Africa and Georgia. A...

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Bibliographic Details
Main Authors: Salim Allana, Elena Shashkina, Barun Mathema, Nino Bablishvili, Nestani Tukvadze, N. Sarita Shah, Russell R. Kempker, Henry M. Blumberg, Pravi Moodley, Koleka Mlisana, James C.M. Brust, Neel R. Gandhi
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2017-03-01
Series:Emerging Infectious Diseases
Subjects:
tuberculosis
drug resistance
South Africa
Georgia
pyrazinamide
sequencing
Online Access:https://wwwnc.cdc.gov/eid/article/23/3/16-1034_article

Internet

https://wwwnc.cdc.gov/eid/article/23/3/16-1034_article

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