Ruscogenin Alleviates Myocardial Ischemia-Induced Ferroptosis through the Activation of BCAT1/BCAT2

Ruscogenin Alleviates Myocardial Ischemia-Induced Ferroptosis through the Activation of BCAT1/BCAT2

Ruscogenin (RUS), a natural steroidal sapogenin, exerts various biological activities. However, its effectiveness for preventing myocardial ischemia (MI) and its molecular mechanisms need further clarification. The model of MI mice and oxygen-glucose deprivation-induced cardiomyocytes injury was per...

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Bibliographic Details
Main Authors: Fei Fu, Qiong Lai, Jingui Hu, Lu Zhang, Xiaozhou Zhu, Junping Kou, Boyang Yu, Fang Li
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Antioxidants
Subjects:
myocardial ischemia
ferroptosis
ruscogenin
metabolomics
BCAT1/BCAT2
Keap1/Nrf2/HO-1 pathway
Online Access:https://www.mdpi.com/2076-3921/11/3/583

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https://www.mdpi.com/2076-3921/11/3/583

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