N-acetylcysteine Counteracts Adipose Tissue Macrophage Infiltration and Insulin Resistance Elicited by Advanced Glycated Albumin in Healthy Rats

Background: Advanced glycation endproducts elicit inflammation. However, their role in adipocyte macrophage infiltration and in the development of insulin resistance, especially in the absence of the deleterious biochemical pathways that coexist in diabetes mellitus, remains unknown. We investigated...

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Main Authors: Karolline S. da Silva, Paula R. Pinto, Nelly T. Fabre, Diego J. Gomes, Karina Thieme, Ligia S. Okuda, Rodrigo T. Iborra, Vanessa G. Freitas, Maria H. M. Shimizu, Walcy R. Teodoro, Suely K. N. Marie, Tom Woods, Margaret A. Brimble, Russell Pickford, Kerry-Anne Rye, Maristela Okamoto, Sergio Catanozi, Maria L. Correa-Giannela, Ubiratan F. Machado, Marisa Passarelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Physiology
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00723/full