Prospective mechanism of action of the tubulysin synthetic derivative (TAM 1344) in HCT116 colon cancer cell line

Prospective mechanism of action of the tubulysin synthetic derivative (TAM 1344) in HCT116 colon cancer cell line

Tubulin is still a highly valued target in cancer chemotherapy. Agents that target tubulin and microtubule dynamic are considered to be of high therapeutic potential. We conducted a study to assess the effects of TAM1344, a synthetic cytolysin that is derived from the natural tubulysins on the proli...

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Bibliographic Details
Main Authors: Aisha Alqarni, Yasser A. Elnakady, Lamya Alsadhan, Muhammad Abbas, Wolfgang Richter, Badr A. Aldahmash, Mansour I. Almansour, Layali M. Almutairi, Ahmed Rady
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Journal of King Saud University: Science
Subjects:
TAM1344
Microtubules
Tubulin
Apoptosis
Caspase-3
Tubulysin
Online Access:http://www.sciencedirect.com/science/article/pii/S1018364723002860

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http://www.sciencedirect.com/science/article/pii/S1018364723002860

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