Hypolipidemic and insulin sensitizing effects of salsalate beyond suppressing inflammation in a prediabetic rat model

Hypolipidemic and insulin sensitizing effects of salsalate beyond suppressing inflammation in a prediabetic rat model

Background and aims: Low-grade chronic inflammation plays an important role in the pathogenesis of metabolic syndrome, type 2 diabetes and their complications. In this study, we investigated the effects of salsalate, a non-steroidal anti-inflammatory drug, on metabolic disturbances in an animal mode...

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Bibliographic Details
Main Authors: Martina Hüttl, Irena Markova, Denisa Miklánková, Iveta Zapletalova, Petr Kujal, Jan Šilhavý, Michal Pravenec, Hana Malinska
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Pharmacology
Subjects:
salsalate
low-grade inflammation
prediabetes
lipid metabolism
cytochrome P450
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1117683/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1117683/full

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