Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid β plaque formation in mice

Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid β plaque formation in mice

Abstract Background Slowed clearance of amyloid β (Aβ) is believed to underlie the development of Aβ plaques that characterize Alzheimer’s disease (AD). Aβ is cleared in part by the glymphatic system, a brain-wide network of perivascular pathways that supports the exchange of cerebrospinal and brain...

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Bibliographic Details
Main Authors: Matthew Simon, Marie Xun Wang, Ozama Ismail, Molly Braun, Abigail G. Schindler, Jesica Reemmer, Zhongya Wang, Mariya A. Haveliwala, Ryan P. O’Boyle, Warren Y. Han, Natalie Roese, Marjorie Grafe, Randall Woltjer, Detlev Boison, Jeffrey J. Iliff
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Aquaporin-4
AQP4
α-Syntrophin
glymphatic
Amyloid β
Online Access:https://doi.org/10.1186/s13195-022-00999-5

Internet

https://doi.org/10.1186/s13195-022-00999-5

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