tappAS: a comprehensive computational framework for the analysis of the functional impact of differential splicing

Abstract Recent advances in long-read sequencing solve inaccuracies in alternative transcript identification of full-length transcripts in short-read RNA-Seq data, which encourages the development of methods for isoform-centered functional analysis. Here, we present tappAS, the first framework to en...

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Bibliographic Details
Main Authors: Lorena de la Fuente, Ángeles Arzalluz-Luque, Manuel Tardáguila, Héctor del Risco, Cristina Martí, Sonia Tarazona, Pedro Salguero, Raymond Scott, Alberto Lerma, Ana Alastrue-Agudo, Pablo Bonilla, Jeremy R. B. Newman, Shunichi Kosugi, Lauren M. McIntyre, Victoria Moreno-Manzano, Ana Conesa
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Genome Biology
Online Access:http://link.springer.com/article/10.1186/s13059-020-02028-w