Integrating thousands of PTEN variant activity and abundance measurements reveals variant subgroups and new dominant negatives in cancers

Integrating thousands of PTEN variant activity and abundance measurements reveals variant subgroups and new dominant negatives in cancers

Abstract Background PTEN is a multi-functional tumor suppressor protein regulating cell growth, immune signaling, neuronal function, and genome stability. Experimental characterization can help guide the clinical interpretation of the thousands of germline or somatic PTEN variants observed in patien...

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Bibliographic Details
Main Authors: Kenneth A. Matreyek, Jason J. Stephany, Ethan Ahler, Douglas M. Fowler
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Genome Medicine
Subjects:
PTEN
Protein variants
Multiplex assays of variant effect
Cancer genomics
Dominant-negative
VAMP-seq
Online Access:https://doi.org/10.1186/s13073-021-00984-x

Internet

https://doi.org/10.1186/s13073-021-00984-x

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