Autocrine prostaglandin E2 signaling promotes tumor cell survival and proliferation in childhood neuroblastoma.

Autocrine prostaglandin E2 signaling promotes tumor cell survival and proliferation in childhood neuroblastoma.

BACKGROUND: Prostaglandin E(2) (PGE(2)) is an important mediator in tumor-promoting inflammation. High expression of cyclooxygenase-2 (COX-2) has been detected in the embryonic childhood tumor neuroblastoma, and treatment with COX inhibitors significantly reduces tumor growth. Here, we have investig...

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Bibliographic Details
Main Authors: Agnes Rasmuson, Anna Kock, Ole Martin Fuskevåg, Björn Kruspig, Jaione Simón-Santamaría, Vladimir Gogvadze, John Inge Johnsen, Per Kogner, Baldur Sveinbjörnsson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3261878?pdf=render

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http://europepmc.org/articles/PMC3261878?pdf=render

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