A Modified Vancomycin Molecule Confers Potent Inhibitory Efficacy against Resistant Bacteria Mediated by Metallo-β-Lactamases

A Modified Vancomycin Molecule Confers Potent Inhibitory Efficacy against Resistant Bacteria Mediated by Metallo-β-Lactamases

Multidrug-resistant bacterial infections mediated by metallo-β-lactamases (MβLs) have grown into an emergent health threat, and development of novel antimicrobials is an ideal strategy to combat the infections. Herein, a novel vancomycin derivative <b>V<sub>b</sub></b> was co...

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Bibliographic Details
Main Authors: Le Zhai, Ya Liu, Yue Jiang, Ling-Yan Kong, Jian Xiao, Yi-Xue Wang, Yang Shi, Yi-Lin Zhang, Ke-Wu Yang
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Molecules
Subjects:
antibiotic resistance
metallo-β-lactamases
vancomycin
triazolylthioacetamide
β-lactam antibiotics
Online Access:https://www.mdpi.com/1420-3049/27/22/7685

Internet

https://www.mdpi.com/1420-3049/27/22/7685

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