Independent functions of DNMT1 and USP7 at replication foci

Independent functions of DNMT1 and USP7 at replication foci

Abstract Background It has been reported that USP7 (ubiquitin-specific protease 7) prevents ubiquitylation and degradation of DNA methyltransferase 1 (DNMT1) by direct binding of USP7 to the glycine-lysine (GK) repeats that join the N-terminal regulatory domain of DNMT1 to the C-terminal methyltrans...

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Bibliographic Details
Main Authors: Olya Yarychkivska, Omid Tavana, Wei Gu, Timothy H. Bestor
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Epigenetics & Chromatin
Subjects:
DNMT1
USP7
Glycine-lysine repeats
Protein stability
Replication foci
Online Access:http://link.springer.com/article/10.1186/s13072-018-0179-z

Internet

http://link.springer.com/article/10.1186/s13072-018-0179-z

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