Therapeutic vulnerabilities in the DNA damage response for the treatment of ATRX mutant neuroblastoma

Therapeutic vulnerabilities in the DNA damage response for the treatment of ATRX mutant neuroblastoma

Background: In neuroblastoma, genetic alterations in ATRX, define a distinct poor outcome patient subgroup. Despite the need for new therapies, there is a lack of available models and a dearth of pre-clinical research. Methods: To evaluate the impact of ATRX loss of function (LoF) in neuroblastoma,...

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Bibliographic Details
Main Authors: Sally L George, Federica Lorenzi, David King, Sabine Hartlieb, James Campbell, Helen Pemberton, Umut H Toprak, Karen Barker, Jennifer Tall, Barbara Martins da Costa, Marlinde L van den Boogaard, M Emmy M Dolman, Jan J Molenaar, Helen E Bryant, Frank Westermann, Christopher J Lord, Louis Chesler
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:EBioMedicine
Subjects:
Neuroblastoma
ATRX
DNA damage response
PARP
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420303479

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http://www.sciencedirect.com/science/article/pii/S2352396420303479

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