Crocin Treatment after Maternal Hypoxia Attenuates Spatial Memory Impairment and Expression of BACE1 and HIF-1α in Rat Offspring Brain

Crocin Treatment after Maternal Hypoxia Attenuates Spatial Memory Impairment and Expression of BACE1 and HIF-1α in Rat Offspring Brain

Objective: Hypoxia via expression of Hypoxia Inducible Factor-1 (HIF-1) is an important and effective factor in the onset and progression of memory disorders such as Alzheimer Disease (AD). The activity of β-secretase (BACE1) increased in hypoxia condition. BACE1 trigger a cascade of pathological ev...

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Bibliographic Details
Main Authors: Fahimeh Fahimi Truski, Zohreh Ghotbeddin, Mohammad Reza Tabandeh, Mahdi Pourmahdi Borujeni
Format: Article
Language:English
Published: Iran University of Medical Sciences 2020-07-01
Series:Basic and Clinical Neuroscience
Subjects:
maternal hypoxia
spatial memory
rat offspring
crocin
hif1
bace1
Online Access:http://bcn.iums.ac.ir/article-1-1483-en.html

Internet

http://bcn.iums.ac.ir/article-1-1483-en.html

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