A structural basis for IκB kinase 2 activation via oligomerization-dependent trans auto-phosphorylation.

A structural basis for IκB kinase 2 activation via oligomerization-dependent trans auto-phosphorylation.

Activation of the IκB kinase (IKK) is central to NF-κB signaling. However, the precise activation mechanism by which catalytic IKK subunits gain the ability to induce NF-κB transcriptional activity is not well understood. Here we report a 4 Å x-ray crystal structure of human IKK2 (hIKK2) in its cata...

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Bibliographic Details
Main Authors: Smarajit Polley, De-Bin Huang, Arthur V Hauenstein, Amanda J Fusco, Xiangyang Zhong, Don Vu, Bärbel Schröfelbauer, Youngchang Kim, Alexander Hoffmann, Inder M Verma, Gourisankar Ghosh, Tom Huxford
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23776406/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23776406/?tool=EBI

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