JAK Kinase Inhibition Abrogates STAT3 Activation and Head and Neck Squamous Cell Carcinoma Tumor Growth

JAK Kinase Inhibition Abrogates STAT3 Activation and Head and Neck Squamous Cell Carcinoma Tumor Growth

Aberrant activation of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) 3 has been implicated in cell proliferation and survival of many cancers including head and neck squamous cell carcinoma (HNSCC). AZD1480, an orally active pharmacologic inhibitor of JAK1/JAK2, has...

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Bibliographic Details
Main Authors: Malabika Sen, Netanya I. Pollock, John Black, Kara A. DeGrave, Sarah Wheeler, Maria L. Freilino, Sonali Joyce, Vivian W.Y. Lui, Yan Zeng, Simion I. Chiosea, Jennifer R. Grandis
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558615000147

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http://www.sciencedirect.com/science/article/pii/S1476558615000147

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