Optimal designs for population pharmacokinetic studies of the partner drugs co-administered with artemisinin derivatives in patients with uncomplicated falciparum malaria
<p>Abstract</p> <p>Background</p> <p>Artemisinin-based combination therapy (ACT) is currently recommended as first-line treatment for uncomplicated malaria, but of concern, it has been observed that the effectiveness of the main artemisinin derivative, artesunate, has b...
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| Format: | Article |
| Language: | English |
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BMC
2012-07-01
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| Series: | Malaria Journal |
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| Online Access: | http://www.malariajournal.com/content/11/1/143 |
| _version_ | 1818787282945048576 |
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| author | Jamsen Kris M Duffull Stephen B Tarning Joel Lindegardh Niklas White Nicholas J Simpson Julie A |
| author_facet | Jamsen Kris M Duffull Stephen B Tarning Joel Lindegardh Niklas White Nicholas J Simpson Julie A |
| author_sort | Jamsen Kris M |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Artemisinin-based combination therapy (ACT) is currently recommended as first-line treatment for uncomplicated malaria, but of concern, it has been observed that the effectiveness of the main artemisinin derivative, artesunate, has been diminished due to parasite resistance. This reduction in effect highlights the importance of the partner drugs in ACT and provides motivation to gain more knowledge of their pharmacokinetic (PK) properties via population PK studies. Optimal design methodology has been developed for population PK studies, which analytically determines a sampling schedule that is clinically feasible and yields precise estimation of model parameters. In this work, optimal design methodology was used to determine sampling designs for typical future population PK studies of the partner drugs (mefloquine, lumefantrine, piperaquine and amodiaquine) co-administered with artemisinin derivatives.</p> <p>Methods</p> <p>The optimal designs were determined using freely available software and were based on structural PK models from the literature and the key specifications of 100 patients with five samples per patient, with one sample taken on the seventh day of treatment. The derived optimal designs were then evaluated via a simulation-estimation procedure.</p> <p>Results</p> <p>For all partner drugs, designs consisting of two sampling schedules (50 patients per schedule) with five samples per patient resulted in acceptable precision of the model parameter estimates.</p> <p>Conclusions</p> <p>The sampling schedules proposed in this paper should be considered in future population pharmacokinetic studies where intensive sampling over many days or weeks of follow-up is not possible due to either ethical, logistic or economical reasons.</p> |
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| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-12-18T14:05:18Z |
| publishDate | 2012-07-01 |
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| series | Malaria Journal |
| spelling | doaj.art-43ed78e6ad3b441584f7c2b82059d2102022-12-21T21:05:15ZengBMCMalaria Journal1475-28752012-07-0111114310.1186/1475-2875-11-143Optimal designs for population pharmacokinetic studies of the partner drugs co-administered with artemisinin derivatives in patients with uncomplicated falciparum malariaJamsen Kris MDuffull Stephen BTarning JoelLindegardh NiklasWhite Nicholas JSimpson Julie A<p>Abstract</p> <p>Background</p> <p>Artemisinin-based combination therapy (ACT) is currently recommended as first-line treatment for uncomplicated malaria, but of concern, it has been observed that the effectiveness of the main artemisinin derivative, artesunate, has been diminished due to parasite resistance. This reduction in effect highlights the importance of the partner drugs in ACT and provides motivation to gain more knowledge of their pharmacokinetic (PK) properties via population PK studies. Optimal design methodology has been developed for population PK studies, which analytically determines a sampling schedule that is clinically feasible and yields precise estimation of model parameters. In this work, optimal design methodology was used to determine sampling designs for typical future population PK studies of the partner drugs (mefloquine, lumefantrine, piperaquine and amodiaquine) co-administered with artemisinin derivatives.</p> <p>Methods</p> <p>The optimal designs were determined using freely available software and were based on structural PK models from the literature and the key specifications of 100 patients with five samples per patient, with one sample taken on the seventh day of treatment. The derived optimal designs were then evaluated via a simulation-estimation procedure.</p> <p>Results</p> <p>For all partner drugs, designs consisting of two sampling schedules (50 patients per schedule) with five samples per patient resulted in acceptable precision of the model parameter estimates.</p> <p>Conclusions</p> <p>The sampling schedules proposed in this paper should be considered in future population pharmacokinetic studies where intensive sampling over many days or weeks of follow-up is not possible due to either ethical, logistic or economical reasons.</p>http://www.malariajournal.com/content/11/1/143Artemisinin-based combination therapyPartner drugsOptimal design |
| spellingShingle | Jamsen Kris M Duffull Stephen B Tarning Joel Lindegardh Niklas White Nicholas J Simpson Julie A Optimal designs for population pharmacokinetic studies of the partner drugs co-administered with artemisinin derivatives in patients with uncomplicated falciparum malaria Malaria Journal Artemisinin-based combination therapy Partner drugs Optimal design |
| title | Optimal designs for population pharmacokinetic studies of the partner drugs co-administered with artemisinin derivatives in patients with uncomplicated falciparum malaria |
| title_full | Optimal designs for population pharmacokinetic studies of the partner drugs co-administered with artemisinin derivatives in patients with uncomplicated falciparum malaria |
| title_fullStr | Optimal designs for population pharmacokinetic studies of the partner drugs co-administered with artemisinin derivatives in patients with uncomplicated falciparum malaria |
| title_full_unstemmed | Optimal designs for population pharmacokinetic studies of the partner drugs co-administered with artemisinin derivatives in patients with uncomplicated falciparum malaria |
| title_short | Optimal designs for population pharmacokinetic studies of the partner drugs co-administered with artemisinin derivatives in patients with uncomplicated falciparum malaria |
| title_sort | optimal designs for population pharmacokinetic studies of the partner drugs co administered with artemisinin derivatives in patients with uncomplicated falciparum malaria |
| topic | Artemisinin-based combination therapy Partner drugs Optimal design |
| url | http://www.malariajournal.com/content/11/1/143 |
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