Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease

Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease

Abstract Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer’s disease (AD), increasing risk and decreasing age of disease onset. Many studies have demonstrated the detrimental effects of apoE4 in varying cellular contexts. However, the underlying mechanisms explaining how apoE4 l...

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Bibliographic Details
Main Authors: Ramsey Najm, Emily A. Jones, Yadong Huang
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Molecular Neurodegeneration
Subjects:
Apolipoprotein E
Alzheimer’s disease
GABAergic interneuron
Hyperexcitability
Inhibitory network
Selective vulnerability
Online Access:http://link.springer.com/article/10.1186/s13024-019-0324-6

Internet

http://link.springer.com/article/10.1186/s13024-019-0324-6

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