Sodium 4-Phenylbutyrate Protects Hypoxic-Ischemic Brain Injury via Attenuating Endoplasmic Reticulum Stress in Neonatal Rats

Sodium 4-Phenylbutyrate Protects Hypoxic-Ischemic Brain Injury via Attenuating Endoplasmic Reticulum Stress in Neonatal Rats

Neonatal hypoxic-ischemic (HI) brain injury is associated with long-term neurological disorders, and protective strategies are presently scarce. Sodium 4-phenylbutyrate (4-PBA) reportedly acts as a chemical chaperone that alleviates endoplasmic reticulum (ER) stress, which plays a critical role in n...

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Bibliographic Details
Main Authors: Ziyi Wu, Jiayuan Niu, Hang Xue, Shuo Wang, Ping Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
sodium 4-phenylbutyrate
endoplasmic reticulum stress
hypoxic-ischemic brain injury
CREB
learning and memory
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2021.632143/full

Internet

https://www.frontiersin.org/articles/10.3389/fnbeh.2021.632143/full

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