Enhancement of the dissolution profile of the diuretic hydrochlorothiazide by elaboration of microspheres

Enhancement of the dissolution profile of the diuretic hydrochlorothiazide by elaboration of microspheres

Hydrochlorothiazide (HCTZ), which was developed and introduced in the late 1950s, is still one of the most frequently employed drugs in antihypertensive treatments. Its poor aqueous solubility is one of the reasons for its limited bioavailability after oral administration. The present paper provides...

Full description

Bibliographic Details
Main Authors: Larbi Oum Cheikh, Merine Haouaria, Ramli Youssef, Toumi Fawzia Benali, Guemra Kaddour, Dehbi Abdelkader
Format: Article
Language:English
Published: Serbian Chemical Society 2018-01-01
Series:Journal of the Serbian Chemical Society
Subjects:
microparticles
polymer carriers
solvent evaporation method
kinetic study
in vitro release
Online Access:http://www.doiserbia.nb.rs/img/doi/0352-5139/2018/0352-51391800065L.pdf

Internet

http://www.doiserbia.nb.rs/img/doi/0352-5139/2018/0352-51391800065L.pdf

Similar Items