Multiscale Model of Antiviral Timing, Potency, and Heterogeneity Effects on an Epithelial Tissue Patch Infected by SARS-CoV-2

Multiscale Model of Antiviral Timing, Potency, and Heterogeneity Effects on an Epithelial Tissue Patch Infected by SARS-CoV-2

We extend our established agent-based multiscale computational model of infection of lung tissue by SARS-CoV-2 to include pharmacokinetic and pharmacodynamic models of remdesivir. We model remdesivir treatment for COVID-19; however, our methods are general to other viral infections and antiviral the...

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Bibliographic Details
Main Authors: Juliano Ferrari Gianlupi, Tarunendu Mapder, T. J. Sego, James P. Sluka, Sara K. Quinney, Morgan Craig, Robert E. Stratford, James A. Glazier
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Viruses
Subjects:
SARS-CoV-2
antiviral therapy
remdesivir
mPBPK
virtual tissue simulation
agent-based model
Online Access:https://www.mdpi.com/1999-4915/14/3/605

Internet

https://www.mdpi.com/1999-4915/14/3/605

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