Shuttling Tolerogenic Dendritic Cells across the Blood–Brain Barrier In Vitro via the Introduction of De Novo C–C Chemokine Receptor 5 Expression Using Messenger RNA Electroporation

Shuttling Tolerogenic Dendritic Cells across the Blood–Brain Barrier In Vitro via the Introduction of De Novo C–C Chemokine Receptor 5 Expression Using Messenger RNA Electroporation

The use of tolerance-inducing dendritic cells (tolDCs) has been proven to be safe and well tolerated in the treatment of autoimmune diseases. Nevertheless, several challenges remain, including finding ways to facilitate the migration of cell therapeutic products to lymph nodes, and the site of infla...

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Bibliographic Details
Main Authors: Maxime De Laere, Judith Derdelinckx, Mari Hassi, Mari Kerosalo, Heidi Oravamäki, Johan Van den Bergh, Zwi Berneman, Nathalie Cools
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
tolerogenic dendritic cells
C–C chemokine receptor 5
messenger RNA electroporation
migration
blood–brain barrier
multiple sclerosis
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01964/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01964/full

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