Quantitative characterization of tumor cell-free DNA shortening

Quantitative characterization of tumor cell-free DNA shortening

Abstract Background Previous studies found that cell-free DNA (cfDNA) generated from tumors was shorter than that from healthy cells, and selecting short cfDNA could enrich for tumor cfDNA and improve its usage in early cancer diagnosis and treatment monitoring; however, the underlying mechanism of...

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Bibliographic Details
Main Authors: Juntang Guo, Kefeng Ma, Hua Bao, Xiangyuan Ma, Yang Xu, Xue Wu, Yang W. Shao, Mei Jiang, Jin Huang
Format: Article
Language:English
Published: BMC 2020-07-01
Series:BMC Genomics
Subjects:
Cell-free DNA
Cancer
Fragment size
Next generation sequencing
Chromatin structure
Nucleosome
Online Access:http://link.springer.com/article/10.1186/s12864-020-06848-9

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http://link.springer.com/article/10.1186/s12864-020-06848-9

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