Pharmacologic Ascorbate and DNMT Inhibitors Increase DUOX Expression and Peroxide-Mediated Toxicity in Pancreatic Cancer

Pharmacologic Ascorbate and DNMT Inhibitors Increase DUOX Expression and Peroxide-Mediated Toxicity in Pancreatic Cancer

Recent studies have demonstrated an important role for vitamin C in the epigenetic regulation of cancer-related genes via DNA demethylation by the ten-eleven translocation (TET) methylcytosine dioxygenase enzymes. DNA methyltransferase (DNMT) reverses this, increasing DNA methylation and decreasing...

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Bibliographic Details
Main Authors: Garett J. Steers, Brianne R. O’Leary, Juan Du, Brett A. Wagner, Rory S. Carroll, Frederick E. Domann, Prabhat C. Goswami, Garry R. Buettner, Joseph J. Cullen
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Antioxidants
Subjects:
ascorbic acid
pharmacologic ascorbate
pancreatic cancer
epigenetics
DNA methyltransferase (DNMT)
ten-eleven translocation (TET) methylcytosine dioxygenase
Online Access:https://www.mdpi.com/2076-3921/12/9/1683

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https://www.mdpi.com/2076-3921/12/9/1683

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