Identification of large genomic rearrangement of BRCA1/2 in high risk patients in Korea

Identification of large genomic rearrangement of BRCA1/2 in high risk patients in Korea

Abstract Background While the majority of germline inactivating mutations in BRCA1/2 are small-scale mutations, large genomic rearrangements (LGRs) are also detected in a variable proportion of patients. However, routine genetic methods are incapable of detecting LGRs, and comprehensive genetic test...

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Bibliographic Details
Main Authors: Do-Hoon Kim, Hyojin Chae, Irene Jo, Jaeeun Yoo, Hyeyoung Lee, Woori Jang, Joonhong Park, Gun Dong Lee, Dong-Seok Jeon, Keun Ho Lee, Soo Young Hur, Byung Joo Chae, Byung Joo Song, Myungshin Kim, Yonggoo Kim
Format: Article
Language:English
Published: BMC 2017-03-01
Series:BMC Medical Genetics
Subjects:
BRCA1
BRCA2
Breast cancer
Ovarian cancer
Genetic testing
Korea
Online Access:http://link.springer.com/article/10.1186/s12881-017-0398-3

Internet

http://link.springer.com/article/10.1186/s12881-017-0398-3

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