Analogs of the Heat Shock Protein 70 Inhibitor MKT-077 Suppress Medullary Thyroid Carcinoma Cells

Analogs of the Heat Shock Protein 70 Inhibitor MKT-077 Suppress Medullary Thyroid Carcinoma Cells

Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor mainly caused by mutations in the <i>RET</i> proto-oncogene. We previously demonstrated that depletion of the mitochondrial molecular chaperone, mortalin, can effectively suppress human MTC cells in culture and in mouse xenograf...

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Bibliographic Details
Main Authors: Seung-Keun Hong, Dmytro Starenki, Oleta T. Johnson, Jason E. Gestwicki, Jong-In Park
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
medullary thyroid carcinoma
mitochondria
mortalin
HSPA9
MKT-077
JG-98
Online Access:https://www.mdpi.com/1422-0067/23/3/1063

Internet

https://www.mdpi.com/1422-0067/23/3/1063

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