Analogs of the Heat Shock Protein 70 Inhibitor MKT-077 Suppress Medullary Thyroid Carcinoma Cells
Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor mainly caused by mutations in the <i>RET</i> proto-oncogene. We previously demonstrated that depletion of the mitochondrial molecular chaperone, mortalin, can effectively suppress human MTC cells in culture and in mouse xenograf...
Main Authors: | Seung-Keun Hong, Dmytro Starenki, Oleta T. Johnson, Jason E. Gestwicki, Jong-In Park |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-01-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/23/3/1063 |
Similar Items
-
Probing Allosteric Hsp70 Inhibitors by Molecular Modelling Studies to Expedite the Development of Novel Combined F508del CFTR Modulators
by: Roberto Sabbadini, et al.
Published: (2021-12-01) -
Mortalin/Hspa9 involvement and therapeutic perspective in Parkinson’s disease
by: Baptiste Texier, et al.
Published: (2023-01-01) -
Anticancer activity of Heat Shock Protein 70 (HSP70) Inhibitor, JG-98, against human cervical cancer HeLa and ovarian cancer SKOV-3 cells
by: Nazan Yurtcu, et al.
Published: (2023-03-01) -
Mortalin: Protein partners, biological impacts, pathological roles, and therapeutic opportunities
by: Niki Esfahanian, et al.
Published: (2023-02-01) -
Clinical Relevance of Mortalin in Ovarian Cancer Patients
by: Alicja Rajtak, et al.
Published: (2023-02-01)