Synthesis and biological evaluation of fluorine substituted pyrazolo[4,3-e][1,2,4]triazines as purine analogues
Some more new fluorine substituted pyrazolo[4,3-e][1,2,4]triazine derivatives (2–5), 7, 10, 14, 17 have been synthesized derived from hydrazinolysis of N-acyl/aroyl/dithioic formamido-2,3-dimethyl-1-phenyl-pyrazolo-5-ones which are obtained from 4-aminoantipyrine 1. The enzymatic assays (cellobaise...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-05-01
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| Series: | Journal of Saudi Chemical Society |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319610316301089 |
| _version_ | 1818595105089519616 |
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| author | Reda M. Abdel-Rahman Rihab F. Angawi Aisha R. Al-Mehmadi |
| author_facet | Reda M. Abdel-Rahman Rihab F. Angawi Aisha R. Al-Mehmadi |
| author_sort | Reda M. Abdel-Rahman |
| collection | DOAJ |
| description | Some more new fluorine substituted pyrazolo[4,3-e][1,2,4]triazine derivatives (2–5), 7, 10, 14, 17 have been synthesized derived from hydrazinolysis of N-acyl/aroyl/dithioic formamido-2,3-dimethyl-1-phenyl-pyrazolo-5-ones which are obtained from 4-aminoantipyrine 1. The enzymatic assays (cellobaise activity) of the new products have been evaluated. |
| first_indexed | 2024-12-16T11:10:43Z |
| format | Article |
| id | doaj.art-440a0d83b0064fb6b0032d719dc29fdc |
| institution | Directory Open Access Journal |
| issn | 1319-6103 |
| language | English |
| last_indexed | 2024-12-16T11:10:43Z |
| publishDate | 2017-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Saudi Chemical Society |
| spelling | doaj.art-440a0d83b0064fb6b0032d719dc29fdc2022-12-21T22:33:44ZengElsevierJournal of Saudi Chemical Society1319-61032017-05-0121449550310.1016/j.jscs.2016.11.004Synthesis and biological evaluation of fluorine substituted pyrazolo[4,3-e][1,2,4]triazines as purine analoguesReda M. Abdel-RahmanRihab F. AngawiAisha R. Al-MehmadiSome more new fluorine substituted pyrazolo[4,3-e][1,2,4]triazine derivatives (2–5), 7, 10, 14, 17 have been synthesized derived from hydrazinolysis of N-acyl/aroyl/dithioic formamido-2,3-dimethyl-1-phenyl-pyrazolo-5-ones which are obtained from 4-aminoantipyrine 1. The enzymatic assays (cellobaise activity) of the new products have been evaluated.http://www.sciencedirect.com/science/article/pii/S13196103163010894-AminoantipyrinePurine analoguesFluorinated pyrazolotriazinesCellobaise activity |
| spellingShingle | Reda M. Abdel-Rahman Rihab F. Angawi Aisha R. Al-Mehmadi Synthesis and biological evaluation of fluorine substituted pyrazolo[4,3-e][1,2,4]triazines as purine analogues Journal of Saudi Chemical Society 4-Aminoantipyrine Purine analogues Fluorinated pyrazolotriazines Cellobaise activity |
| title | Synthesis and biological evaluation of fluorine substituted pyrazolo[4,3-e][1,2,4]triazines as purine analogues |
| title_full | Synthesis and biological evaluation of fluorine substituted pyrazolo[4,3-e][1,2,4]triazines as purine analogues |
| title_fullStr | Synthesis and biological evaluation of fluorine substituted pyrazolo[4,3-e][1,2,4]triazines as purine analogues |
| title_full_unstemmed | Synthesis and biological evaluation of fluorine substituted pyrazolo[4,3-e][1,2,4]triazines as purine analogues |
| title_short | Synthesis and biological evaluation of fluorine substituted pyrazolo[4,3-e][1,2,4]triazines as purine analogues |
| title_sort | synthesis and biological evaluation of fluorine substituted pyrazolo 4 3 e 1 2 4 triazines as purine analogues |
| topic | 4-Aminoantipyrine Purine analogues Fluorinated pyrazolotriazines Cellobaise activity |
| url | http://www.sciencedirect.com/science/article/pii/S1319610316301089 |
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