Donor HLA−DR Drives the Development of De Novo Autoimmunity Following Lung and Heart Transplantation

Donor HLA−DR Drives the Development of De Novo Autoimmunity Following Lung and Heart Transplantation

Background. Individuals harbor preexisting HLA−DR/DQ−restricted responses to collagen type V (ColV) mediated by Th17 cells under Treg control, both specific to peptides that bind to inherited HLA class II antigens. Yet after transplant, the donor−DR type somehow influences graft outcome. We hypothes...

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Bibliographic Details
Main Authors: Ewa Jankowska−Gan, MS, Vrushali V. Agashe, PhD, Diego A. Lema, MD, Ying Zhou, MS, Laura Gonzalez Bosc, PhD, Jeremy A. Sullivan, PhD, Daniel S. Greenspan, PhD, William J. Burlingham, PhD
Format: Article
Language:English
Published: Wolters Kluwer 2020-10-01
Series:Transplantation Direct
Online Access:http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000001062

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http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000001062

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