Altered lung morphogenesis, epithelial cell differentiation and mechanics in mice deficient in the Wnt/β-catenin antagonist Chibby.

Altered lung morphogenesis, epithelial cell differentiation and mechanics in mice deficient in the Wnt/β-catenin antagonist Chibby.

The canonical Wnt/β-catenin pathway plays crucial roles in various aspects of lung morphogenesis and regeneration/repair. Here, we examined the lung phenotype and function in mice lacking the Wnt/β-catenin antagonist Chibby (Cby). In support of its inhibitory role in canonical Wnt signaling, express...

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Bibliographic Details
Main Authors: Damon Love, Feng-Qian Li, Michael C Burke, Benjamin Cyge, Masao Ohmitsu, Jeffrey Cabello, Janet E Larson, Steven L Brody, J Craig Cohen, Ken-Ichi Takemaru
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2963606?pdf=render

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http://europepmc.org/articles/PMC2963606?pdf=render

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