Modulation of the immune system by the gut microbiota in the development of type 1 diabetes
T1D is an autoimmune disease characterized by T cell-mediated destruction of insulin-producing β-cells in the pancreatic islets of Langerhans, resulting in hyperglycemia, with patients requiring lifelong insulin treatment. Many studies have shown that genetics alone are not sufficient for the increa...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-11-01
|
| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2018.1514354 |
| _version_ | 1797677468180545536 |
|---|---|
| author | James A. Pearson Andrew Agriantonis F. Susan Wong Li Wen |
| author_facet | James A. Pearson Andrew Agriantonis F. Susan Wong Li Wen |
| author_sort | James A. Pearson |
| collection | DOAJ |
| description | T1D is an autoimmune disease characterized by T cell-mediated destruction of insulin-producing β-cells in the pancreatic islets of Langerhans, resulting in hyperglycemia, with patients requiring lifelong insulin treatment. Many studies have shown that genetics alone are not sufficient for the increase in T1D incidence and thus other factors have been suggested to modify the disease risk. T1D incidence has sharply increased in the developed world, especially amongst youth. In Europe, T1D incidence is increasing at an annual rate of 3–4%. Increasing evidence shows that gut microbiota, as one of the environmental factors influencing diabetes development, play an important role in development of T1D. Here, we summarize the current knowledge about the relationship between the microbiota and T1D. We also discuss the possibility of T1D prevention by changing the composition of gut microbiota. |
| first_indexed | 2024-03-11T22:44:40Z |
| format | Article |
| id | doaj.art-44117b47428741f190cdf93b2ef882c0 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:44:40Z |
| publishDate | 2018-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-44117b47428741f190cdf93b2ef882c02023-09-22T08:38:23ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2018-11-0114112580259610.1080/21645515.2018.15143541514354Modulation of the immune system by the gut microbiota in the development of type 1 diabetesJames A. Pearson0Andrew Agriantonis1F. Susan Wong2Li Wen3Yale UniversityYale UniversityCardiff UniversityYale UniversityT1D is an autoimmune disease characterized by T cell-mediated destruction of insulin-producing β-cells in the pancreatic islets of Langerhans, resulting in hyperglycemia, with patients requiring lifelong insulin treatment. Many studies have shown that genetics alone are not sufficient for the increase in T1D incidence and thus other factors have been suggested to modify the disease risk. T1D incidence has sharply increased in the developed world, especially amongst youth. In Europe, T1D incidence is increasing at an annual rate of 3–4%. Increasing evidence shows that gut microbiota, as one of the environmental factors influencing diabetes development, play an important role in development of T1D. Here, we summarize the current knowledge about the relationship between the microbiota and T1D. We also discuss the possibility of T1D prevention by changing the composition of gut microbiota.http://dx.doi.org/10.1080/21645515.2018.1514354gut microbiotatype 1 diabetesnod micetherapy |
| spellingShingle | James A. Pearson Andrew Agriantonis F. Susan Wong Li Wen Modulation of the immune system by the gut microbiota in the development of type 1 diabetes Human Vaccines & Immunotherapeutics gut microbiota type 1 diabetes nod mice therapy |
| title | Modulation of the immune system by the gut microbiota in the development of type 1 diabetes |
| title_full | Modulation of the immune system by the gut microbiota in the development of type 1 diabetes |
| title_fullStr | Modulation of the immune system by the gut microbiota in the development of type 1 diabetes |
| title_full_unstemmed | Modulation of the immune system by the gut microbiota in the development of type 1 diabetes |
| title_short | Modulation of the immune system by the gut microbiota in the development of type 1 diabetes |
| title_sort | modulation of the immune system by the gut microbiota in the development of type 1 diabetes |
| topic | gut microbiota type 1 diabetes nod mice therapy |
| url | http://dx.doi.org/10.1080/21645515.2018.1514354 |
| work_keys_str_mv | AT jamesapearson modulationoftheimmunesystembythegutmicrobiotainthedevelopmentoftype1diabetes AT andrewagriantonis modulationoftheimmunesystembythegutmicrobiotainthedevelopmentoftype1diabetes AT fsusanwong modulationoftheimmunesystembythegutmicrobiotainthedevelopmentoftype1diabetes AT liwen modulationoftheimmunesystembythegutmicrobiotainthedevelopmentoftype1diabetes |