Tracking of an Oral Salmonella-Based Vaccine for Type 1 Diabetes in Non-obese Diabetic Mice

Tracking of an Oral Salmonella-Based Vaccine for Type 1 Diabetes in Non-obese Diabetic Mice

Type 1 diabetes (T1D) arises secondary to immune-driven destruction of pancreatic β-cells and manifests as insulin-deficient hyperglycemia. We showed that oral vaccination with live attenuated Salmonella, which simultaneously delivers autoantigens and a TGFβ expression vector to immune cells in the...

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Bibliographic Details
Main Authors: Jacques C. Mbongue, Ali Alhoshani, Jeffrey Rawson, Pablo A. Garcia, Nelson Gonzalez, Kevin Ferreri, Fouad Kandeel, Mohamed I. Husseiny
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
Salmonella-based vaccine
sleeping beauty
transposons
Type 1 Diabetes
CD103+DC
TGFβ
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00712/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00712/full

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