A binding site for phosphoinositides described by multiscale simulations explains their modulation of voltage-gated sodium channels
Voltage-gated sodium channels (Naᵥ) are membrane proteins which open to facilitate the inward flux of sodium ions into excitable cells. In response to stimuli, Naᵥ channels transition from the resting, closed state to an open, conductive state, before rapidly inactivating. Dysregulation of this func...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2024-03-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/91218 |