A binding site for phosphoinositides described by multiscale simulations explains their modulation of voltage-gated sodium channels

A binding site for phosphoinositides described by multiscale simulations explains their modulation of voltage-gated sodium channels

Voltage-gated sodium channels (Naᵥ) are membrane proteins which open to facilitate the inward flux of sodium ions into excitable cells. In response to stimuli, Naᵥ channels transition from the resting, closed state to an open, conductive state, before rapidly inactivating. Dysregulation of this func...

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Bibliographic Details
Main Authors: Yiechang Lin, Elaine Tao, James P Champion, Ben Corry
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-03-01
Series:eLife
Subjects:
sodium channel
molecular dynamics
phosphoinositide
lipid-protein interaction
inactivation
ion channel
Online Access:https://elifesciences.org/articles/91218

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