New endoperoxides highly active in vivo and in vitro against artemisinin-resistant Plasmodium falciparum

New endoperoxides highly active in vivo and in vitro against artemisinin-resistant Plasmodium falciparum

Abstract Background The emergence and spread of Plasmodium falciparum resistance to artemisinin-based combination therapy in Southeast Asia prompted the need to develop new endoperoxide-type drugs. Methods A chemically diverse library of endoperoxides was designed and synthesized. The compounds were...

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Bibliographic Details
Main Authors: Lis Lobo, Lília I. L. Cabral, Maria Inês Sena, Bruno Guerreiro, António Sebastião Rodrigues, Valter Ferreira de Andrade-Neto, Maria L. S. Cristiano, Fatima Nogueira
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Malaria Journal
Subjects:
Plasmodium falciparum
Antimalarial drug resistance
Trioxolane–tetrazole conjugates
Tetraoxane–tetrazole conjugates
In vivo antimalarial activity
Online Access:http://link.springer.com/article/10.1186/s12936-018-2281-x

Internet

http://link.springer.com/article/10.1186/s12936-018-2281-x

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