Priming with Recombinant BCG Expressing HTI Enhances the Magnitude and Breadth of the T-Cell Immune Responses Elicited by MVA.HTI in BALB/c Mice

Priming with Recombinant BCG Expressing HTI Enhances the Magnitude and Breadth of the T-Cell Immune Responses Elicited by MVA.HTI in BALB/c Mice

The use of <i>Mycobacterium bovis</i> bacillus Calmette–Guérin (BCG) as a live vaccine vehicle is a promising approach for HIV-1-specific T-cell induction. In this study, we used recombinant BCG expressing HIVACAT T-cell immunogen (HTI), BCG.HTI<sup>2auxo.int</sup>. BALB/c mi...

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Bibliographic Details
Main Authors: Narcís Saubi, Athina Kilpeläinen, Yoshiki Eto, Chun-Wei Chen, Àlex Olvera, Tomáš Hanke, Christian Brander, Joan Joseph-Munné
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Vaccines
Subjects:
BCG
HIV-1
vaccine
rBCG
HTI
T-cell
Online Access:https://www.mdpi.com/2076-393X/8/4/678

Internet

https://www.mdpi.com/2076-393X/8/4/678

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