Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination

Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination

Oligodendrocytes (OLs) myelinate axons and provide electrical insulation and trophic support for neurons in the central nervous system (CNS). Platelet-derived growth factor (PDGF) is critical for steady-state number and differentiation of oligodendrocyte precursor cells (OPCs), but its downstream ta...

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Bibliographic Details
Main Authors: Liang Zhou, Chong-Yu Shao, Ya-Jun Xie, Na Wang, Si-Min Xu, Ben-Yan Luo, Zhi-Ying Wu, Yue Hai Ke, Mengsheng Qiu, Ying Shen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-01-01
Series:eLife
Subjects:
oligodendrocyte
myelin
Gab1
PDGF
GSK3β
Online Access:https://elifesciences.org/articles/52056

Internet

https://elifesciences.org/articles/52056

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