Characterization of target gene regulation by the two Epstein-Barr virus oncogene LMP1 domains essential for B-cell transformation

Characterization of target gene regulation by the two Epstein-Barr virus oncogene LMP1 domains essential for B-cell transformation

ABSTRACTThe Epstein-Barr virus (EBV) oncogene latent membrane protein 1 (LMP1) mimics CD40 signaling and is expressed by multiple malignancies. Two LMP1 C-terminal cytoplasmic tail regions, termed transformation essential sites (TES) 1 and 2, are critical for EBV transformation of B lymphocytes into...

Full description

Bibliographic Details
Main Authors: Bidisha Mitra, Nina Rose Beri, Rui Guo, Eric M. Burton, Laura A. Murray-Nerger, Benjamin E. Gewurz
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:mBio
Subjects:
gammaherpesvirus
lymphoproliferative disease
tumor virus
B-cell oncogenesis
interferon regulatory factor
BATF
Online Access:https://journals.asm.org/doi/10.1128/mbio.02338-23

Internet

https://journals.asm.org/doi/10.1128/mbio.02338-23

Similar Items