Anti-HLA Class I alloantibodies in platelet transfusion refractoriness: From mechanisms and determinants to therapeutic prospects

Anti-HLA Class I alloantibodies in platelet transfusion refractoriness: From mechanisms and determinants to therapeutic prospects

Patients with hematological disorders and severe thrombocytopenia require extensive and iterative platelet transfusion support. In these patients, platelet transfusion refractoriness represents a serious adverse transfusion event with major outcomes for patient care. Recipient alloantibodies against...

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Bibliographic Details
Main Authors: Adèle Couvidou, Gabriel Rojas-Jiménez, Arnaud Dupuis, Blandine Maître
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
HLA class I
alloantibodies
transfusion
platelets
refractoriness (platelets)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1125367/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1125367/full

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