Characterisation and prion transmission study in mice with genetic reduction of sporadic Creutzfeldt-Jakob disease risk gene Stx6

Characterisation and prion transmission study in mice with genetic reduction of sporadic Creutzfeldt-Jakob disease risk gene Stx6

Sporadic Creutzfeldt-Jakob disease (sCJD), the most common human prion disease, is thought to occur when the cellular prion protein (PrPC) spontaneously misfolds and assembles into prion fibrils, culminating in fatal neurodegeneration. In a genome-wide association study of sCJD, we recently identifi...

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Bibliographic Details
Main Authors: Emma Jones, Elizabeth Hill, Jacqueline Linehan, Tamsin Nazari, Adam Caulder, Gemma F. Codner, Marie Hutchison, Matthew Mackenzie, Michael Farmer, Thomas Coysh, Michael Wiggins De Oliveira, Huda Al-Doujaily, Malin Sandberg, Emmanuelle Viré, Thomas J. Cunningham, Emmanuel A. Asante, Sebastian Brandner, John Collinge, Simon Mead
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Neurobiology of Disease
Subjects:
Prion disease
Creutzfeldt-Jakob disease
SNARE
Syntaxin-6
Incubation period
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123003790

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http://www.sciencedirect.com/science/article/pii/S0969996123003790

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