Hypoxia-induced lncRNA STEAP3-AS1 activates Wnt/β-catenin signaling to promote colorectal cancer progression by preventing m6A-mediated degradation of STEAP3 mRNA

Hypoxia-induced lncRNA STEAP3-AS1 activates Wnt/β-catenin signaling to promote colorectal cancer progression by preventing m6A-mediated degradation of STEAP3 mRNA

Abstract Background Hypoxia, a typical hallmark of solid tumors, exhibits an essential role in the progression of colorectal cancer (CRC), in which the dysregulation of long non-coding RNAs (lncRNAs) is frequently observed. However, the underlying mechanisms are not clearly defined. Methods The TCGA...

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Bibliographic Details
Main Authors: Li Zhou, Jingwen Jiang, Zhao Huang, Ping Jin, Liyuan Peng, Maochao Luo, Zhe Zhang, Yan Chen, Na Xie, Wei Gao, Edouard C. Nice, Jing-Quan Li, Hai-Ning Chen, Canhua Huang
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Molecular Cancer
Subjects:
Hypoxia
LncRNA STEAPS-AS1
STEAP3
m6A modification
YTHDF2
Wnt/β-catenin
Online Access:https://doi.org/10.1186/s12943-022-01638-1

Internet

https://doi.org/10.1186/s12943-022-01638-1

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