Deep learning model of somatic hypermutation reveals importance of sequence context beyond hotspot targeting
Summary: B cells undergo somatic hypermutation (SHM) of the Immunoglobulin (Ig) variable region to generate high-affinity antibodies. SHM relies on the activity of activation-induced deaminase (AID), which mutates C>U preferentially targeting WRC (W=A/T, R=A/G) hotspots. Downstream mutations at W...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2022-01-01
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Series: | iScience |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004221016382 |