Nucleoside supplements as treatments for mitochondrial DNA depletion syndrome

Nucleoside supplements as treatments for mitochondrial DNA depletion syndrome

Introduction: In mitochondrial DNA (mtDNA) depletion syndrome (MDS), patients cannot maintain sufficient mtDNA for their energy needs. MDS presentations range from infantile encephalopathy with hepatopathy (Alpers syndrome) to adult chronic progressive external ophthalmoplegia. Most are caused by nu...

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Bibliographic Details
Main Authors: Eszter Dombi, Tony Marinaki, Paolo Spingardi, Val Millar, Nastasia Hadjichristou, Janet Carver, Iain G. Johnston, Carl Fratter, Joanna Poulton
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
mitochondrial DNA
mitochondrial DNA depletion syndrome
high-content imaging
nucleoside bypass therapy
heavy isotope labelling mass spectroscopy
alpers syndrome
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2024.1260496/full

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https://www.frontiersin.org/articles/10.3389/fcell.2024.1260496/full

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