Estimation of relative biological effectiveness of 225Ac compared to 177Lu during [225Ac]Ac-PSMA and [177Lu]Lu-PSMA radiopharmaceutical therapy using TOPAS/TOPAS-nBio/MEDRAS

Estimation of relative biological effectiveness of 225Ac compared to 177Lu during [225Ac]Ac-PSMA and [177Lu]Lu-PSMA radiopharmaceutical therapy using TOPAS/TOPAS-nBio/MEDRAS

Abstract Aim Over recent years, [225Ac]Ac-PSMA and [177Lu]Lu-PSMA radiopharmaceutical therapy have evolved as a promising treatment option for advanced prostate cancer. Especially for alpha particle emitter treatments, there is still a need for improving dosimetry, which requires accurate values of...

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Bibliographic Details
Main Authors: Mikhail Rumiantcev, Wei Bo Li, Simon Lindner, Grigory Liubchenko, Sandra Resch, Peter Bartenstein, Sibylle I. Ziegler, Guido Böning, Astrid Delker
Format: Article
Language:English
Published: SpringerOpen 2023-09-01
Series:EJNMMI Physics
Subjects:
mCRPC
Radiopharmaceutical therapy
[225Ac]Ac-PSMA
[177Lu]Lu-PSMA
RBE
Online Access:https://doi.org/10.1186/s40658-023-00567-2

Internet

https://doi.org/10.1186/s40658-023-00567-2

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