Integrative molecular analyses define correlates of high B7-H3 expression in metastatic castrate-resistant prostate cancer

Integrative molecular analyses define correlates of high B7-H3 expression in metastatic castrate-resistant prostate cancer

Abstract B7-H3 (CD276) is an immune checkpoint overexpressed in prostate cancer with minimal expression in normal tissues and associated with poor prognosis, making it an excellent therapy target. We interrogated B7-H3 expression and its regulation in metastatic castration-resistant prostate cancer...

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Bibliographic Details
Main Authors: Xiaolei Shi, Abderrahman Day, Hannah E. Bergom, Sydney Tape, Sylvan C. Baca, Zoi E. Sychev, Gabrianne Larson, Asha Bozicevich, Justin M. Drake, Nicholas Zorko, Jinhua Wang, Charles J. Ryan, Emmanuel S. Antonarakis, Justin Hwang
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-022-00323-2

Internet

https://doi.org/10.1038/s41698-022-00323-2

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