Internalization of <i>Clostridium botulinum</i> C2 Toxin Is Regulated by Cathepsin B Released from Lysosomes

Internalization of <i>Clostridium botulinum</i> C2 Toxin Is Regulated by Cathepsin B Released from Lysosomes

<i>Clostridium botulinum</i> C2 toxin is a clostridial binary toxin consisting of actin ADP-ribosyltransferase (C2I) and C2II binding components. Activated C2II (C2IIa) binds to cellular receptors and forms oligomer in membrane rafts. C2IIa oligomer assembles with C2I and contributes to...

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Bibliographic Details
Main Authors: Masahiro Nagahama, Keiko Kobayashi, Sadayuki Ochi, Masaya Takehara
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Toxins
Subjects:
<i>C. botulinum</i> C2 toxin
internalization
cathepsin B
Online Access:https://www.mdpi.com/2072-6651/13/4/272

Internet

https://www.mdpi.com/2072-6651/13/4/272

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